Motor abnormalities among children with PANS and/or PANDAS
Erika Unsbo
10.6084/m9.figshare.4584034.v2
https://figshare.com/articles/journal_contribution/Motoriska_avvikelser_hos_barn_med_PANS_och_eller_PANDAS/4584034
<p><i>Introduction: </i>Pediatric Acute-onset Neuropsychiatric
Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric disorders Associated
with Streptococcal Infections (PANDAS) are putative diagnoses with symptoms
including tics and obsessive compulsive disorder. These disorders are believed
to be caused by antibodies against the basal ganglia. Some reports show that
these patients have affected motor control. This may be explained by the
hypothesis that antibodies against the basal ganglia cause the disorders. <i>Aims: </i>This study aimed to compare the
presence of motor abnormalities among patients with PANS and/or PANDAS and age-
and sex-matched healthy persons. <i>Material
and Methods: </i>17 persons aged 8-19 years that had been diagnosed with PANS
and/or PANDAS in Sweden were included in the study. 25 controls were matched
with the patients regarded age and sex. Both groups were then examined with 6
tests of motor function. The tests were scored and groups were compared using
linear regression. The total score for the test was 0-22 where 0 points indicated
a test performed without any impairments and 22 points was a test performed
with large difficulty. <i>Results: </i>The mean
score for the patients was 8.2 points and the mean score for the controls was 4.5
points, indicating a higher presence of motor abnormalities among patients with
PANS and/or PANDAS. The effect adjusted for age was 3.7 points lower for the
controls compared to the patients, p = 0.0004. <i>Conclusions: </i>Our results suggest that patients with PANS and/or
PANDAS have more motor abnormalities compared to age and sex matched controls.</p>
2017-01-28 09:50:40
Motor abnormalities
PANS
PANDAS
Psychiatry (incl. Psychotherapy)