Additional file 1: of Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy BrachatArndt GromAlexei WulffraatNico BrunnerHermine QuartierPierre BrikRiva McCannLiza OzdoganHuri Rutkowska-SakLidia SchneiderRayfel GerloniValeria HarelLiora TerreriMaria HoughtonKristin JoosRik KingsburyDaniel Lopez-BenitezJorge BekStephan SchumacherMartin ValentinMarie-Anne GramHermann AbramsKen MartiniAlberto LovellDaniel NirmalaNanguneri RupertoNicolino 2017 Table S1 Definition of adapted ACR JIA response. Table S2 Genes with ≥3-fold differential expression between patients with SJIA and healthy controls, prior to canakinumab treatment. Table S3 List of independent ethics committees or institutional review boards (trial 1). Table S4 List of independent ethics committees or institutional review boards (trial 2). (DOCX 53 kb)