10.6084/m9.figshare.4557889.v1
Márkus R.
Márkus
R.
Lerner Z.
Lerner
Z.
Honti V.
Honti
V.
Csordás G.
Csordás
G.
Zsámboki J.
Zsámboki
J.
Cinege G.
Cinege
G.
Párducz Á.
Párducz
Á.
Lukacsovich T.
Lukacsovich
T.
Kurucz É.
Kurucz
É.
Andó I.
Andó
I.
Supplementary Material for: Multinucleated Giant Hemocytes Are Effector Cells in Cell-Mediated Immune Responses of Drosophila
Karger Publishers
2017
Comparative immunology
Drosophila
Encapsulation
Granuloma
Host defense
Immune responses
Insects
Multinucleated giant hemocytes
Parasitology
2017-01-17 13:48:41
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Multinucleated_Giant_Hemocytes_Are_Effector_Cells_in_Cell-Mediated_Immune_Responses_of_Drosophila/4557889
<p>We identified and characterized a so far unrecognized cell type<i>,</i>
dubbed the multinucleated giant hemocyte (MGH), in the ananassae
subgroup of Drosophilidae. Here, we describe the functional and
ultrastructural characteristics of this novel blood cell type as well as
its characterization with a set of discriminative immunological
markers. MGHs are encapsulating cells that isolate and kill the parasite
without melanization. They share some properties with but differ
considerably from lamellocytes, the encapsulating cells of <i>Drosophila melanogaster</i>,
the broadly used model organism in studies of innate immunity. MGHs are
nonproliferative effector cells that are derived from phagocytic cells
of the sessile tissue and the circulation, but do not exhibit phagocytic
activity. In contrast to lamellocytes, MGHs are gigantic cells with
filamentous projections and contain many nuclei, which are the result of
the fusion of several cells. Although the structure of lamellocytes and
MGHs differ remarkably, their function in the elimination of parasites
is similar, which is potentially the result of the convergent evolution
of interactions between hosts and parasites in different geographic
regions. MGHs are highly motile and share several features with
mammalian multinucleated giant cells, a syncytium of macrophages formed
during granulomatous inflammation.</p>