10.6084/m9.figshare.4546948.v1 Kerstin Sarter Kerstin Sarter Manuel Kulagin Manuel Kulagin Georg Schett Georg Schett Nicola L. Harris Nicola L. Harris Mario M. Zaiss Mario M. Zaiss Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites Taylor & Francis Group 2017 Arthritis helminths excretory–secretory products bone metabolism osteoclast 2017-01-13 11:19:58 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Inflammatory_arthritis_and_systemic_bone_loss_are_attenuated_by_gastrointestinal_helminth_parasites/4546948 <p>Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, <i>Heligmosomoides polygyrus bakeri</i> (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore, we show that excretory–secretory (ES) products from Hp directly suppress osteoclast differentiation <i>in vitro</i>. Taken together, these results demonstrate that helminth infections can dampen autoimmune diseases and highlight a previously unrecognized and important role for ES products, by directly impacting on bone destruction.</p>