10.6084/m9.figshare.4546948.v1
Kerstin Sarter
Kerstin
Sarter
Manuel Kulagin
Manuel
Kulagin
Georg Schett
Georg
Schett
Nicola L. Harris
Nicola
L. Harris
Mario M. Zaiss
Mario
M. Zaiss
Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites
Taylor & Francis Group
2017
Arthritis
helminths
excretory–secretory products
bone metabolism
osteoclast
2017-01-13 11:19:58
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Inflammatory_arthritis_and_systemic_bone_loss_are_attenuated_by_gastrointestinal_helminth_parasites/4546948
<p>Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, <i>Heligmosomoides polygyrus bakeri</i> (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore, we show that excretory–secretory (ES) products from Hp directly suppress osteoclast differentiation <i>in vitro</i>. Taken together, these results demonstrate that helminth infections can dampen autoimmune diseases and highlight a previously unrecognized and important role for ES products, by directly impacting on bone destruction.</p>