10.4225/03/587c016a06f47
Nisbet, David Russell
David Russell
Nisbet
Development of neural tissue engineering scaffolds for guided neurite extension within the central nervous system
Monash University
2017
In vivo
In vitro
thesis(doctorate)
Scaffold
ethesis-20090704-020927
monash:10267
Open access
Central nervous system
Electrospinning
Neural tissue engineering
2009
Hydrogel
1959.1/79137
Mollie Holman Doctoral Medal for Excellence
2017-01-15 23:10:32
Thesis
https://bridges.monash.edu/articles/thesis/Development_of_neural_tissue_engineering_scaffolds_for_guided_neurite_extension_within_the_central_nervous_system/4546129
This thesis reports on the development of two unique neural tissue engineering scaffolds
for cellular support and guided neurite extension within the central nervous system
(CNS). For this reason this work is presented in 3 Parts to allow for a thorough
understanding to be obtained, in regard to the development and characterisation of each
unique neural tissue engineering scaffold; Part I focuses on the development of
nanoscale polymer fibres produced using electrospinning; Part II is concerned with the
examination of smart xyloglucan hydrogels, which are injected into the body as a liquid
and then assemble forming a hydrogel scaffold when the temperature is raised to 37 ºC.
Part III contains the final chapter and links the preceding Parts so that ultimately the
benefits of each can be incorporated into a 'composite' scaffold. Such a scaffold may
generate individual cellular niche environments that are more permissible for cell
differentiation and maintenance or for directed axonal regeneration through mimicking
some of the neurochemical and neuroanatomical architecture of physiological tissue. <div><br></div><div>Awards: Winner of the Mollie Holman Doctoral Medal for Excellence, Faculty of Engineering, 2009.</div>