Anwar, Sirajudheen Crouch, Rebecca A. Ali, Nasser A. Awadh Al-Fatimi, Mohamed A. N. Setzer, William Wessjohann, Ludger Hierarchical cluster analysis and chemical characterisation of <i>Myrtus communis</i> L. essential oil from Yemen region and its antimicrobial, antioxidant and anti-colorectal adenocarcinoma properties <p>The hydrodistilled essential oil obtained from the dried leaves of <i>Myrtus communis</i>, collected in Yemen, was analysed by GC–MS. Forty-one compounds were identified, representing 96.3% of the total oil. The major constituents of essential oil were oxygenated monoterpenoids (87.1%), linalool (29.1%), 1,8-cineole (18.4%), α-terpineol (10.8%), geraniol (7.3%) and linalyl acetate (7.4%). The essential oil was assessed for its antimicrobial activity using a disc diffusion assay and resulted in moderate to potent antibacterial and antifungal activities targeting mainly <i>Bacillus subtilis, Staphylococcus aureus</i> and <i>Candida albicans.</i> The oil moderately reduced the diphenylpicrylhydrazyl radical (IC<sub>50</sub> = 4.2 μL/mL or 4.1 mg/mL). <i>In vitro</i> cytotoxicity evaluation against HT29 (human colonic adenocarcinoma cells) showed that the essential oil exhibited a moderate antitumor effect with IC<sub>50</sub> of 110 ± 4 μg/mL. Hierarchical cluster analysis of <i>M. communis</i> has been carried out based on the chemical compositions of 99 samples reported in the literature, including Yemeni sample.</p> Myrtus;essential oil;cytotoxicity;Yemen;GC-MS 2017-01-10
    https://tandf.figshare.com/articles/journal_contribution/Hierarchical_cluster_analysis_and_chemical_characterisation_of_i_Myrtus_communis_i_L_essential_oil_from_Yemen_region_and_its_antimicrobial_antioxidant_and_anti-colorectal_adenocarcinoma_properties/4535339
10.6084/m9.figshare.4535339.v1