Transmission electron microscopy images of chimeric VLP. Bettina Huber Christina Schellenbacher Saeed Shafti-Keramat Christoph Jindra Neil Christensen Reinhard Kirnbauer 10.1371/journal.pone.0169533.g002 https://plos.figshare.com/articles/figure/Transmission_electron_microscopy_images_of_chimeric_VLP_/4521965 <p>Purified preparations of HPV5L1-17RG1 <b>(A)</b>, HPV16L1-17RG1 <b>(B)</b>, HPV1L1-4RG1 <b>(C)</b>, HPV16L1-5L2(aa53-72) <b>(D)</b> and HPV18L1-5L2(aa53-72) <b>(E)</b> were negatively stained and visualized at 30,000-fold magnification. The size bars represent 200nm. +, tubular structures composed of pentamers; *, co-purified baculovirus contaminant.</p> 2017-01-05 18:57:18 HPV 4 challenge chimeric proteins self-assembled capsid proteins non-melanoma skin cancer HPV 16 L 1 VLP murine PsV challenge model VLP-raised NZW rabbit 12 novel beta PsV types mucosal HPV infections HPV 16L VLP RG 1 homolog RG 1-based VLP Chimeric L 2-Based Virus-Like Particle HPV 5L VLP cross-protected HPV 5L aa 53-72 epitope cutaneous HPV types HPV 16 L 2 cross-neutralization epitope RG 1 L 2 peptide HPV 1L VLP cross-protected species beta HPV 18 L 1 VLP scaffolds ELISA HPV 17 RG 1 epitope cutaneous HPV 4 RG 1 homolog DE surface loops Experimental papillomavirus vaccines generation vaccine candidates target cutaneous HPV infections target cutaneous HPV Licensed HPV vaccines type-common neutralization epitopes Vaccines Targeting Cutaneous Human Papillomaviruses L 1 fusion proteins target heterologous HPV NMSC L 2-based pseudovirion