Effects of ACO on sodium currents in Guinea-pig ventricular myocytes. Jianjun Wu Xiangchong Wang Ying Ying Chung Cai Hong Koh Zhenfeng Liu Huicai Guo Qiang Yuan Chuan Wang Suwen Su Heming Wei 10.1371/journal.pone.0168435.g007 https://plos.figshare.com/articles/figure/Effects_of_ACO_on_sodium_currents_in_Guinea-pig_ventricular_myocytes_/4521260 <p>(A) Representative traces of the peak I<sub>Na</sub> recorded in a Guinea-pig ventricular myocyte prior to and after 3 μM ACO. (B) The I-V curves showing the current densities of peak I<sub>Na</sub>. n = 5. (C) The SS-inactivation and -activation curves. n = 5. (D) The I-V curves of the voltage-gated I<sub>NaL</sub> densities. n = 5. (E) Representative traces of voltage-dependent I<sub>NaL</sub> recorded in a Guinea-pig ventricular myocyte prior to and post 3μM ACO. *<i>p</i> < 0.05, <sup>†</sup><i>p</i> < 0.01, vs. baseline.</p> 2017-01-05 18:46:50 proarrhythmic effects ventricular-like hiPSC-CMs action potentials Human Cardiomyocytes Aconitine i transients channel opening microelectrode arrays assay APD Laser-scanning confocal calcium imaging analysis LTCC inhibition proarrhythmic action heterologous expression systems L-type calcium channel Na ACO cell-derived cardiomyocytes L-Type Calcium Channel Inhibition Contributes rectifier potassium Proarrhythmic Effects AP voltage-clamping assays