Effects of ACO on sodium currents in Guinea-pig ventricular myocytes.
Jianjun Wu
Xiangchong Wang
Ying Ying Chung
Cai Hong Koh
Zhenfeng Liu
Huicai Guo
Qiang Yuan
Chuan Wang
Suwen Su
Heming Wei
10.1371/journal.pone.0168435.g007
https://plos.figshare.com/articles/figure/Effects_of_ACO_on_sodium_currents_in_Guinea-pig_ventricular_myocytes_/4521260
<p>(A) Representative traces of the peak I<sub>Na</sub> recorded in a Guinea-pig ventricular myocyte prior to and after 3 μM ACO. (B) The I-V curves showing the current densities of peak I<sub>Na</sub>. n = 5. (C) The SS-inactivation and -activation curves. n = 5. (D) The I-V curves of the voltage-gated I<sub>NaL</sub> densities. n = 5. (E) Representative traces of voltage-dependent I<sub>NaL</sub> recorded in a Guinea-pig ventricular myocyte prior to and post 3μM ACO. *<i>p</i> < 0.05, <sup>†</sup><i>p</i> < 0.01, vs. baseline.</p>
2017-01-05 18:46:50
proarrhythmic effects
ventricular-like hiPSC-CMs
action potentials
Human Cardiomyocytes Aconitine
i transients
channel opening
microelectrode arrays assay
APD
Laser-scanning confocal calcium imaging analysis
LTCC inhibition
proarrhythmic action
heterologous expression systems
L-type calcium channel
Na
ACO
cell-derived cardiomyocytes
L-Type Calcium Channel Inhibition Contributes
rectifier potassium
Proarrhythmic Effects
AP
voltage-clamping assays