SNc DA neuron physiology.
Chad M. Estep
Daniel J. Galtieri
Enrico Zampese
Joshua A. Goldberg
Lars Brichta
Paul Greengard
D. James Surmeier
10.1371/journal.pone.0169044.g001
https://plos.figshare.com/articles/figure/SNc_DA_neuron_physiology_/4506962
<p>(A) 2P reconstruction of SNc DA neuron. (B) Left, normal pacemaking of a SNc DA neuron. Middle, TTX (1 μM) application uncovered slow oscillatory potential (SOP). Right, 5 μM baclofen application hyperpolarized the cell. (C) Summary of hyperpolarization due to application of 5 μM baclofen (n = 8, median = -25.24 mV). (D) Sustained uncaging of 5 μM RuBi-GABA in the presence of 25 μM gabazine (to block GABA<sub>A</sub> receptors) hyperpolarized cells in a manner similar to that seen following baclofen application. (E) Summary of hyperpolarization due to sustained 5 μM RuBi-GABA uncaging (n = 7, median = -11.71 mV).</p>
2016-12-30 18:34:22
calcium-activated K
GABA B receptor activation
pause-burst pattern
burst spiking
GABA B receptors hyperpolarized SNc DA neurons
Sustained stimulation
GABA B Receptors Suppresses SK Channel Currents
spike generation
protein kinase
Transient Activation
SK channel activity increases
GABA B receptors
Substantia Nigra Pars Compacta Dopaminergic Neurons Dopaminergic
postsynaptic effects
GABAergic neurons
patch recordings
adenylyl cyclase
adult mouse SNc DA neurons
substantia nigra pars compacta
SNc DA neurons