SNc DA neuron physiology. Chad M. Estep Daniel J. Galtieri Enrico Zampese Joshua A. Goldberg Lars Brichta Paul Greengard D. James Surmeier 10.1371/journal.pone.0169044.g001 https://plos.figshare.com/articles/figure/SNc_DA_neuron_physiology_/4506962 <p>(A) 2P reconstruction of SNc DA neuron. (B) Left, normal pacemaking of a SNc DA neuron. Middle, TTX (1 μM) application uncovered slow oscillatory potential (SOP). Right, 5 μM baclofen application hyperpolarized the cell. (C) Summary of hyperpolarization due to application of 5 μM baclofen (n = 8, median = -25.24 mV). (D) Sustained uncaging of 5 μM RuBi-GABA in the presence of 25 μM gabazine (to block GABA<sub>A</sub> receptors) hyperpolarized cells in a manner similar to that seen following baclofen application. (E) Summary of hyperpolarization due to sustained 5 μM RuBi-GABA uncaging (n = 7, median = -11.71 mV).</p> 2016-12-30 18:34:22 calcium-activated K GABA B receptor activation pause-burst pattern burst spiking GABA B receptors hyperpolarized SNc DA neurons Sustained stimulation GABA B Receptors Suppresses SK Channel Currents spike generation protein kinase Transient Activation SK channel activity increases GABA B receptors Substantia Nigra Pars Compacta Dopaminergic Neurons Dopaminergic postsynaptic effects GABAergic neurons patch recordings adenylyl cyclase adult mouse SNc DA neurons substantia nigra pars compacta SNc DA neurons