Supplementary Material for: Associations of Serum Osteocalcin and Polymorphisms of the Osteocalcin Gene with Bone Mineral Density in Postmenopausal and Elderly Chinese Women
Zhang X.-Y.
He J.-W.
Fu W.-Z.
Liu Y.-J.
Zhang Z.-L.
10.6084/m9.figshare.4488140.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Associations_of_Serum_Osteocalcin_and_Polymorphisms_of_the_Osteocalcin_Gene_with_Bone_Mineral_Density_in_Postmenopausal_and_Elderly_Chinese_Women/4488140
<p><b><i>Background:</i></b> The aims of this study were: (1) to
evaluate the association of serum osteocalcin with bone mineral density
(BMD) and markers of bone metabolism in postmenopausal and elderly
Chinese women, and (2) to observe the relationships of single-nucleotide
polymorphisms (SNPs) in and around the <i>osteocalcin</i> gene with osteocalcin and BMD. <b><i>Methods:</i></b>
A cross-sectional study was conducted with 725 postmenopausal Chinese
women. Five SNPs (rs1543294, rs1800247, rs759330, rs2842880, and
rs933489) of the <i>osteocalcin</i> gene were genotyped. Serum
osteocalcin and intact parathyroid hormone (PTH), 25-hydroxyvitamin D
[25(OH)D], and type I collagen containing cross-linked C-telopeptide
(β-CTX) were measured. The BMD of the lumbar spine and proximal femur
was measured by dual-energy X-ray absorptiometry. <b><i>Results:</i></b> Osteocalcin was positively correlated with serum phosphorus (<i>p</i> = 0.001), alkaline phosphatase (ALP; <i>p</i> < 0.001), PTH (<i>p</i> = 0.002) and β-CTX (<i>p</i> < 0.001), and negatively correlated with BMD at the lumbar spine (<i>p</i> < 0.001) and total hip (<i>p</i> = 0.002). No significant association was obtained between the SNPs, haplotypes of the <i>osteocalcin</i> gene, and BMD or osteocalcin. <b><i>Conclusion:</i></b>
Our results suggest that osteocalcin was positively correlated with
serum phosphorus, ALP, PTH, and β-CTX, but negatively correlated with
BMD at the lumbar spine and total hip. Common genetic variants of the <i>osteocalcin</i> gene may not be a major contributor to variations in serum osteocalcin or BMD in postmenopausal and elderly Chinese women.</p>
2016-12-21 16:08:46
single-nucleotide polymorphisms
Polymorphism
Haplotypes
Bone mineral density
Osteocalcin