%0 Journal Article %A Cui, Qing %A Zhao, Hong %A Luo, Guangsheng %A Xu, Jianhong %D 2016 %T An Efficient Chitosan/Silica Composite Core–Shell Microspheres-Supported Pd Catalyst for Aryl Iodides Sonogashira Coupling Reactions %U https://acs.figshare.com/articles/journal_contribution/An_Efficient_Chitosan_Silica_Composite_Core_Shell_Microspheres-Supported_Pd_Catalyst_for_Aryl_Iodides_Sonogashira_Coupling_Reactions/4487852 %R 10.1021/acs.iecr.6b04077.s001 %2 https://ndownloader.figshare.com/files/7234550 %K microfluidic device %K Pd %K terminal alkynes %K aryl iodides %K metal catalyst %K Aryl Iodides Sonogashira %K 5 mg %X Monodispersed chitosan/silica core–shell microspheres-supported Pd catalysts were prepared by a simple and affordable microfluidic device. Merely 5 mg of supported Pd catalyst (1 wt %) showed superior capability in Sonogashira coupling reactions between various aryl iodides and terminal alkynes in a mild environment (ligand-free, copper-free, amine-free, water–ethanol as solvent at 65 °C) even after eight cycles of use. These novel porous composite microspheres provide a new carrier to reduce the loading, enhance the activity, and increase the stability of noble metal catalyst. %I ACS Publications