Cui, Qing Zhao, Hong Luo, Guangsheng Xu, Jianhong An Efficient Chitosan/Silica Composite Core–Shell Microspheres-Supported Pd Catalyst for Aryl Iodides Sonogashira Coupling Reactions Monodispersed chitosan/silica core–shell microspheres-supported Pd catalysts were prepared by a simple and affordable microfluidic device. Merely 5 mg of supported Pd catalyst (1 wt %) showed superior capability in Sonogashira coupling reactions between various aryl iodides and terminal alkynes in a mild environment (ligand-free, copper-free, amine-free, water–ethanol as solvent at 65 °C) even after eight cycles of use. These novel porous composite microspheres provide a new carrier to reduce the loading, enhance the activity, and increase the stability of noble metal catalyst. microfluidic device;Pd;terminal alkynes;aryl iodides;metal catalyst;Aryl Iodides Sonogashira;5 mg 2016-12-07
    https://acs.figshare.com/articles/media/An_Efficient_Chitosan_Silica_Composite_Core_Shell_Microspheres-Supported_Pd_Catalyst_for_Aryl_Iodides_Sonogashira_Coupling_Reactions/4487849
10.1021/acs.iecr.6b04077.s002