TY - DATA T1 - Spiro Meroterpenoids from Ganoderma applanatum PY - 2016/12/20 AU - Qi Luo AU - Xiao-Yi Wei AU - Jing Yang AU - Jin-Feng Luo AU - Rui Liang AU - Zheng-Chao Tu AU - Yong-Xian Cheng UR - https://acs.figshare.com/articles/journal_contribution/Spiro_Meroterpenoids_from_i_Ganoderma_applanatum_i_/4483706 DO - 10.1021/acs.jnatprod.6b00431.s001 L4 - https://ndownloader.figshare.com/files/7223489 KW - spectroscopic methods KW - compounds 7 KW - fungus Ganoderma applanatum KW - fruiting bodies KW - Spiro Meroterpenoids KW - JAK 3 kinase KW - IC 50 values KW - 13 C NMR calculations KW - ECD KW - spiro meroterpenoids KW - Ganoderma applanatum Spiroapplanatumines KW - single-crystal X-ray diffraction analysis KW - Biological evaluation N2 - Spiroapplanatumines A–Q (1–12, 14–16, 18, and 20), new spiro meroterpenoids respectively bearing a 6/5/7 or 6/5/5 ring system, along with three known compounds, spirolingzhines A, B, and D, were isolated from the fruiting bodies of the fungus Ganoderma applanatum. Their structures including absolute configurations were assigned by using spectroscopic methods, ECD and 13C NMR calculations, and single-crystal X-ray diffraction analysis. Biological evaluation of all the compounds disclosed that compounds 7 and 8 inhibited JAK3 kinase with IC50 values of 7.0 ± 3.2 and 34.8 ± 21.1 μM, respectively. ER -