Luo, Qi Wei, Xiao-Yi Yang, Jing Luo, Jin-Feng Liang, Rui Tu, Zheng-Chao Cheng, Yong-Xian Spiro Meroterpenoids from <i>Ganoderma applanatum</i> Spiroapplanatumines A–Q (<b>1</b>–<b>12</b>, <b>14</b>–<b>16</b>, <b>18</b>, and <b>20</b>), new spiro meroterpenoids respectively bearing a 6/5/7 or 6/5/5 ring system, along with three known compounds, spirolingzhines A, B, and D, were isolated from the fruiting bodies of the fungus <i>Ganoderma applanatum</i>. Their structures including absolute configurations were assigned by using spectroscopic methods, ECD and <sup>13</sup>C NMR calculations, and single-crystal X-ray diffraction analysis. Biological evaluation of all the compounds disclosed that compounds <b>7</b> and <b>8</b> inhibited JAK3 kinase with IC<sub>50</sub> values of 7.0 ± 3.2 and 34.8 ± 21.1 μM, respectively. spectroscopic methods;compounds 7;fungus Ganoderma applanatum;fruiting bodies;Spiro Meroterpenoids;JAK 3 kinase;IC 50 values;13 C NMR calculations;ECD;spiro meroterpenoids;Ganoderma applanatum Spiroapplanatumines;single-crystal X-ray diffraction analysis;Biological evaluation 2016-12-20
    https://acs.figshare.com/articles/dataset/Spiro_Meroterpenoids_from_i_Ganoderma_applanatum_i_/4483703
10.1021/acs.jnatprod.6b00431.s002