TY - DATA T1 - Supplementary Material for: Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis PY - 2016/12/20 AU - D'Arrigo G. AU - Baggetta R. AU - Tripepi G. AU - Galli F. AU - Bolignano D. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Effects_of_Vitamin_E-Coated_versus_Conventional_Membranes_in_Chronic_Hemodialysis_Patients_A_Systematic_Review_and_Meta-Analysis/4483391 DO - 10.6084/m9.figshare.4483391.v1 L4 - https://ndownloader.figshare.com/files/7222514 L4 - https://ndownloader.figshare.com/files/7222517 L4 - https://ndownloader.figshare.com/files/7222520 L4 - https://ndownloader.figshare.com/files/7222523 L4 - https://ndownloader.figshare.com/files/7222526 KW - Vitamin E-coated membrane KW - Oxidative stress KW - Inflammation KW - Anemia KW - Hemodialysis N2 - Introduction: Accruing evidence suggests that vitamin E-coated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients. Methods: We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status. Results: Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid. Conclusions: ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials. ER -