10.6084/m9.figshare.c.3646397_D1.v1 M. Brahimi-Horn M. Brahimi-Horn Sandy Giuliano Sandy Giuliano Estelle Saland Estelle Saland Sandra Lacas-Gervais Sandra Lacas-Gervais Tatiana Sheiko Tatiana Sheiko Joffrey Pelletier Joffrey Pelletier Isabelle Bourget Isabelle Bourget Frédéric Bost Frédéric Bost Chloé Féral Chloé Féral Etienne Boulter Etienne Boulter Michel Tauc Michel Tauc Mircea Ivan Mircea Ivan Barbara Garmy-Susini Barbara Garmy-Susini Alexandra Popa Alexandra Popa Bernard Mari Bernard Mari Jean-Emmanuel Sarry Jean-Emmanuel Sarry William Craigen William Craigen Jacques Pouysségur Jacques Pouysségur Nathalie Mazure Nathalie Mazure Additional file 10: Figure S5. of Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation Springer Nature 2015 presence ebselen absence inflammation Glutathione peroxidase expression reactive oxygen species generation 72  h normoxia GPX 7 Wt MEF Vdac 1 activates hypoxia-inducible factor HIF -1α tumor growth 2015-08-26 05:00:00 Journal contribution https://springernature.figshare.com/articles/journal_contribution/Additional_file_10_Figure_S5_of_Knockout_of_Vdac1_activates_hypoxia-inducible_factor_through_reactive_oxygen_species_generation_and_induces_tumor_growth_by_promoting_metabolic_reprogramming_and_inflammation/4475123 Glutathione peroxidase expression and the effect of ebselen. (A) Immunofluorescence to GPX7 in Wt and Vdac1 −/− MEF in Nx or Hx for 72 h. (B) Immunoblotting for HIF-1α of Wt and Vdac1 −/− MEF in the absence or presence of ebselen in normoxia. (C) Proliferation of Wt and Vdac1 −/− MEF in the absence or presence of ebselen in normoxia. (D) Viability of Wt and Vdac1 −/− MEF in the absence or presence of ebselen in normoxia.