10.1371/journal.pone.0168342.g003 John P. Marken John P. Marken Andrew D. Halleran Andrew D. Halleran Atiqur Rahman Atiqur Rahman Laura Odorizzi Laura Odorizzi Michael C. LeFew Michael C. LeFew Caroline A. Golino Caroline A. Golino Peter Kemper Peter Kemper Margaret S. Saha Margaret S. Saha Parameter choices do not qualitatively change the biological interpretation of our information entropy measure. Public Library of Science 2016 calcium dynamics Calcium Activity Time Series Methods fractal analysis approaches murine synaptic neurons Markovian Entropy Measure implementable calcium time series analysis method displays activity time series dataset Markovian Entropy measure time series data calcium activity calcium analysis methods 2016-12-15 19:22:09 Figure https://plos.figshare.com/articles/figure/Parameter_choices_do_not_qualitatively_change_the_biological_interpretation_of_our_information_entropy_measure_/4449566 <p>Cohen’s d statistic [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0168342#pone.0168342.ref029" target="_blank">29</a>] comparing distributions of entropy values for cellular calcium activity of (a) stage 14 and stage 18 <i>Xenopus laevis</i> embryos, (b) stage 18 and stage 22 <i>Xenopus laevis</i> embryos, (c) stage 14 and stage 22 <i>Xenopus laevis</i> embryos, and (d) mature retrotrapezoid nucleus neurons from embryonic mice in pH 7.4 solution vs. pH 7.2 solution (data in (d) obtained from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0168342#pone.0168342.ref015" target="_blank">15</a>]). At large values of <i>n</i> and <i>k</i>, a sign change in d value occurs which is a technical artifact arising from there being more entries in the transition matrix than can be filled by data from our time series. The numerical values of d which generated this figure can be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0168342#pone.0168342.s007" target="_blank">S2 Table</a>.</p>