Duran, Javier Oyarce, Cesar Pavez, Mario Valladares, Denisse Basualto-Alarcon, Carla Lagos, Daniel Barrientos, Genaro Troncoso, Mayarling Francisca Ibarra, Cristian Estrada, Manuel PI3K/Akt signaling is involved in GSK-3β inhibition. <p>Cardiac myocytes were pretreated for 30 min with Akt-inhibitor VIII (Akti-VIII, 10 μM), LY-294002 (10 μM), or PD98059 (50 μM) prior to testosterone stimulation (100 nM) by 30 min. The densitometry results show the ratio of phosphorylated protein to total protein (n = 4 for each condition). Values are presented as the mean ± SEM. *p < 0.05 <i>vs</i>. control.</p> GSK -3β phosphorylation;GSK -3β;Thr 41. GSK -3β inhibition;β- catenin protein accumulation;GSK -3βS;glycogen synthase kinase -3β;calcineurin inhibitors FK 506;NFAT-Luc activity;β- catenin phosphorylation;GSK -3β activation;myocyte hypertrophy;intracellular androgen receptor;Testosterone-Induced Cardiac Myocyte Hypertrophy Testosterone;100 nM testosterone;GSK -3β activity;R-VIVIT;testosterone-induced NFAT-Luc activation;modulating NFAT activity;GSK -3β-targeting siRNA;GSK -3β inhibition 2016-12-15
    https://plos.figshare.com/articles/figure/PI3K_Akt_signaling_is_involved_in_GSK-3_inhibition_/4448648
10.1371/journal.pone.0168255.g004