10.6084/m9.figshare.c.3632936_D8.v1
Thomas Southworth
Thomas
Southworth
Jonathan Plumb
Jonathan
Plumb
Vandana Gupta
Vandana
Gupta
James Pearson
James
Pearson
Isabel Ramis
Isabel
Ramis
Martin Lehner
Martin
Lehner
Montserrat Miralpeix
Montserrat
Miralpeix
Dave Singh
Dave
Singh
Additional file 9: Figure S3. of Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients
Springer Nature
2016
Asthma
Phosphatidylinositol 3-kinase delta
JAK/STAT
T-cell cytokines
Bronchoscopy
2016-10-04 05:00:00
Presentation
https://springernature.figshare.com/articles/presentation/Additional_file_9_Figure_S3_of_Anti-inflammatory_potential_of_PI3K_and_JAK_inhibitors_in_asthma_patients/4429880
Effects of Dexamethasone, PIK-294 and tofacinib on IL-6 from TCR-stimulated BAL cells. BAL cells from asthma patients (n = 5) were treated with varying concentrations of dexamethasone with or without 100nM of tofacitinib for 1 h before being stimulated with antibodies against CD3 and CD28 to induce a TCR-specific response. IL-6 was measured by ELISA. Data is presented as mean +/− standard deviation. Drug effects were analysed by 1-way ANOVA: p = 0.22. (PPTX 89 kb)