10.6084/m9.figshare.c.3616889_D5.v1 Margarita Olympiou Margarita Olympiou Irene Sargiannidou Irene Sargiannidou Kyriaki Markoullis Kyriaki Markoullis Christos Karaiskos Christos Karaiskos Alexia Kagiava Alexia Kagiava Styliana Kyriakoudi Styliana Kyriakoudi Charles Abrams Charles Abrams Kleopas Kleopa Kleopas Kleopa Additional file 1: Figure S1. of Systemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease Springer Nature 2016 CMT1X Cx47 Cx43 LPS model Oligodendrocytes Gap junctions 2016-09-01 05:00:00 Figure https://springernature.figshare.com/articles/figure/Additional_file_1_Figure_S1_of_Systemic_inflammation_disrupts_oligodendrocyte_gap_junctions_and_induces_ER_stress_in_a_model_of_CNS_manifestations_of_X-linked_Charcot-Marie-Tooth_disease/4380989 1 LPS induces IL-6 and TNF-α increase in Cx32 KO mice. a-b: Graphs representing concentration course of IL-6 before (0 h) as well as 4, 24, and 96 h after saline (a) or LPS (b) injection as measured at 450 nm with ELISA. Saline did not cause any significant systemic inflammation (baseline inflammation: 0.14 pg/mL, 4 h after injection: 0.23 pg/mL), whereas a marked increase 4 h after LPS injection (935.1 pg/mL) was found. c-d: Levels of TNF-α before (0 h) as well as after (4, 24, 96 h) saline (c) and LPS (d) injection; saline did not cause any inflammatory response (baseline: 0.21 pg/mL, at 4 h: 0.22 pg/mL) whereas LPS injection caused a marked TNF-α increase (4 h after injection: 22.08 pg/mL). (TIF 12301 kb)