10.6084/m9.figshare.c.3616889_D5.v1
Margarita Olympiou
Margarita
Olympiou
Irene Sargiannidou
Irene
Sargiannidou
Kyriaki Markoullis
Kyriaki
Markoullis
Christos Karaiskos
Christos
Karaiskos
Alexia Kagiava
Alexia
Kagiava
Styliana Kyriakoudi
Styliana
Kyriakoudi
Charles Abrams
Charles
Abrams
Kleopas Kleopa
Kleopas
Kleopa
Additional file 1: Figure S1. of Systemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease
Springer Nature
2016
CMT1X
Cx47
Cx43
LPS model
Oligodendrocytes
Gap junctions
2016-09-01 05:00:00
Figure
https://springernature.figshare.com/articles/figure/Additional_file_1_Figure_S1_of_Systemic_inflammation_disrupts_oligodendrocyte_gap_junctions_and_induces_ER_stress_in_a_model_of_CNS_manifestations_of_X-linked_Charcot-Marie-Tooth_disease/4380989
1 LPS induces IL-6 and TNF-α increase in Cx32 KO mice. a-b: Graphs representing concentration course of IL-6 before (0 h) as well as 4, 24, and 96 h after saline (a) or LPS (b) injection as measured at 450 nm with ELISA. Saline did not cause any significant systemic inflammation (baseline inflammation: 0.14 pg/mL, 4 h after injection: 0.23 pg/mL), whereas a marked increase 4 h after LPS injection (935.1 pg/mL) was found. c-d: Levels of TNF-α before (0 h) as well as after (4, 24, 96 h) saline (c) and LPS (d) injection; saline did not cause any inflammatory response (baseline: 0.21 pg/mL, at 4 h: 0.22 pg/mL) whereas LPS injection caused a marked TNF-α increase (4 h after injection: 22.08 pg/mL). (TIF 12301 kb)