%0 Figure %A Laine, Elodie %A Chauvot de Beauchêne, Isaure %A Perahia, David %A Auclair, Christian %A Tchertanov, Luba %D 2011 %T MD simulations of KIT cytoplasmic region in the auto-inhibited inactive form. %U https://plos.figshare.com/articles/figure/_MD_simulations_of_KIT_cytoplasmic_region_in_the_auto_inhibited_inactive_form_/434677 %R 10.1371/journal.pcbi.1002068.g002 %2 https://ndownloader.figshare.com/files/764308 %K simulations %K cytoplasmic %K auto-inhibited %K inactive %X

The RMS deviations (in Å) were calculated from MD simulations of full-length CR for wild-type KIT, WT547-935 (in blue), and D816V mutant, MU547-935 (in red), on the backbone atoms of (a) the whole CR, (b) N-lobe, (c) C-lobe, (d) A-loop and (e) JMR. The 50-ns simulations 1 and 2 of the wild-type (mutant, respectively) are shown by plain and dashed lines. The dashed grey vertical line drawn at 2 ns indicates the relaxation time.

%I PLOS Computational Biology