%0 Journal Article %A Adjalley, Sophie %A Scanfeld, Daniel %A Kozlowski, Elyse %A Llinás, Manuel %A Fidock, David %D 2015 %T Additional file 1: Figure S1. of Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1 %U https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_Figure_S1_of_Genome-wide_transcriptome_profiling_reveals_functional_networks_involving_the_Plasmodium_falciparum_drug_resistance_transporters_PfCRT_and_PfMDR1/4345049 %R 10.6084/m9.figshare.c.3605153_D16.v1 %2 https://ndownloader.figshare.com/files/7071050 %K Plasmodium falciparum %K Antimalarial drug resistance %K Comparative transcriptomics %K Transporters %K Fast fourier transform %K Gene set enrichment analysis %K Hypergeometric analysis of time series %X Schema summarizing the parental and transgenic parasite lines used in this study. (A) The FCB data set comprises FCB, FCB pfmdr1_3′KD and 106/1 (not pictured). FCB pfmdr1_3′KD was derived from the multidrug-resistant strain FCB by genetically disrupting one of the two copies of the pfmdr1 gene, as reported in [26]. pBS: pBluescript plasmid backbone. Δmdr: pfmdr1 fragment used to disrupt the coding sequence in one of the two endogenous tandem pfmdr1 loci in FCB, resulting in FCB pfmdr1-3′KD (knock-down). (B) The 7G8 data set comprises the CQ-resistant parental strain 7G8 (PfCRT haplotype T76), from which two transgenic lines were derived by allelic exchange as previously described [20], namely the control 7G8 pfcrt_CTL (moderately CQ-resistant, PfCRT haplotype T76) and the back-mutant 7G8 pfcrt_T76K that is now fully CQ-sensitive (PfCRT haplotype K76). (PDF 347 kb) %I figshare