TY - DATA T1 - Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives PY - 2016/12/07 AU - Shawn D. Nelson AU - Mathias J. Wawer AU - Stuart L. Schreiber UR - https://acs.figshare.com/articles/dataset/Divergent_Synthesis_and_Real-Time_Biological_Annotation_of_Optically_Active_Tetrahydrocyclopenta_i_c_i_pyranone_Derivatives/4292288 DO - 10.1021/acs.orglett.6b03118.s002 L4 - https://ndownloader.figshare.com/files/7000934 KW - fingerprint KW - probe KW - pyranone Derivatives Sp 3 KW - Divergent Synthesis KW - promise KW - Real-Time KW - multiplexed measurements KW - Optically KW - cyclization KW - geometrie KW - Annotation KW - Pauson KW - collection KW - single-enantiomer bicyclic KW - complexity-generating KW - Tetrahydrocyclopenta KW - compound KW - annotation KW - cyclopentenone KW - alteration KW - drug-discovery KW - synthesis N2 - Sp3-rich compounds are underrepresented in libraries for probe- and drug-discovery, despite their promise of extending the range of accessible molecular shapes beyond planar geometries. With this in mind, a collection of single-enantiomer bicyclic, fused cyclopentenones underpinned by a complexity-generating Pauson–Khand cyclization was synthesized. A fingerprint of biological actions of these compounds was determined immediately after synthesis using real-time annotation−a process relying on multiplexed measurements of alterations in cell morphological features. ER -