%0 Generic
%A Nelson, Shawn
D.
%A Wawer, Mathias J.
%A Schreiber, Stuart L.
%D 2016
%T Divergent Synthesis and Real-Time Biological Annotation
of Optically Active Tetrahydrocyclopenta[c]pyranone
Derivatives
%U https://acs.figshare.com/articles/dataset/Divergent_Synthesis_and_Real-Time_Biological_Annotation_of_Optically_Active_Tetrahydrocyclopenta_i_c_i_pyranone_Derivatives/4292288
%R 10.1021/acs.orglett.6b03118.s002
%2 https://ndownloader.figshare.com/files/7000934
%K fingerprint
%K probe
%K pyranone Derivatives Sp 3
%K Divergent Synthesis
%K promise
%K Real-Time
%K multiplexed measurements
%K Optically
%K cyclization
%K geometrie
%K Annotation
%K Pauson
%K collection
%K single-enantiomer bicyclic
%K complexity-generating
%K Tetrahydrocyclopenta
%K compound
%K annotation
%K cyclopentenone
%K alteration
%K drug-discovery
%K synthesis
%X Sp3-rich compounds are underrepresented in libraries
for probe- and drug-discovery, despite their promise of extending
the range of accessible molecular shapes beyond planar geometries.
With this in mind, a collection of single-enantiomer bicyclic, fused
cyclopentenones underpinned by a complexity-generating Pauson–Khand
cyclization was synthesized. A fingerprint of biological actions of
these compounds was determined immediately after synthesis using real-time
annotation−a process relying on multiplexed measurements of
alterations in cell morphological features.
%I ACS Publications