%0 Generic %A Nelson, Shawn D. %A Wawer, Mathias J. %A Schreiber, Stuart L. %D 2016 %T Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives %U https://acs.figshare.com/articles/dataset/Divergent_Synthesis_and_Real-Time_Biological_Annotation_of_Optically_Active_Tetrahydrocyclopenta_i_c_i_pyranone_Derivatives/4292288 %R 10.1021/acs.orglett.6b03118.s002 %2 https://ndownloader.figshare.com/files/7000934 %K fingerprint %K probe %K pyranone Derivatives Sp 3 %K Divergent Synthesis %K promise %K Real-Time %K multiplexed measurements %K Optically %K cyclization %K geometrie %K Annotation %K Pauson %K collection %K single-enantiomer bicyclic %K complexity-generating %K Tetrahydrocyclopenta %K compound %K annotation %K cyclopentenone %K alteration %K drug-discovery %K synthesis %X Sp3-rich compounds are underrepresented in libraries for probe- and drug-discovery, despite their promise of extending the range of accessible molecular shapes beyond planar geometries. With this in mind, a collection of single-enantiomer bicyclic, fused cyclopentenones underpinned by a complexity-generating Pauson–Khand cyclization was synthesized. A fingerprint of biological actions of these compounds was determined immediately after synthesis using real-time annotation−a process relying on multiplexed measurements of alterations in cell morphological features. %I ACS Publications