%0 Conference Paper %A Martinic, Marina Krnic %A Utrobicic, Ana %A Simic, Josip %A Gabelica, Mirko %A Mahmic-Kaknjo, Mersiha %A Krleza-Jeric, Karmela %D 2016 %T Clinical trial data sharing in the 21st century: a scoping review of the literature, IMPACT Observatory %U https://figshare.com/articles/poster/Clinical_trial_data_sharing_in_the_21st_century_a_scoping_review_of_the_literature_IMPACT_Observatory/4245356 %R 10.6084/m9.figshare.4245356.v1 %2 https://ndownloader.figshare.com/files/6923846 %2 https://ndownloader.figshare.com/files/6927905 %K Clinical trial transparency %K clinical trial data sharing %K trial results reporting %K Clinical Trial Registration %K Clinical Trial Data %K IMPACT Observatory %K Ottawa statement %K scoping review %K Barriers to data sharing %K publication bias %K Aggregate data %K raw data %K clinical trial raw data %K policy %K guidelines %K standards %K Medical and Health Sciences not elsewhere classified %K Public Health and Health Services not elsewhere classified %X

Presented: 8th Croatian Cochrane Symposium, Split, Croatia, May 2016

The overall goal of the IMPACT Observatory is assessing ongoing transitions of clinical trial research regarding data sharing due to the increasing understanding of the importance of reanalysis of raw data for advancement of science, reducing research waste, and increasing the reliability of evidence gained by systematic reviews of clinical trials (CTs).

This poster presents the preliminary results of a scoping review of literature aiming to assess the dynamics of clinical trial data transparency and related changes of culture, policies and practice since the baseline set in year 2000.

In the analysis of 132 selected papers the changes in CT data sharing since 2000 were mapped. The focus of the scientific community evolved from publication bias over protocol disclosure to sharing of aggregate and raw data and forming databases and registries with open access. Players include journal editors, publishers, researchers, funders, pharmaceutical industry, media, consumers, and regulators.

Data sharing, culture, guidelines, standards, policies, and databases are the main topics discussed. The lack of methods and standards of data sharing are identified as the main gaps.

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