Li, Lei Li, Huan Peng, Xing-Rong Hou, Bo Yu, Mu-Yuan Dong, Jin-Run Li, Xiao-Nian Zhou, Lin Yang, Jian Qiu, Ming-Hua (±)-Ganoapplanin, a Pair of Polycyclic Meroterpenoid Enantiomers from <i>Ganoderma applanatum</i> (±)-Ganoapplanin (<b>1</b>), a pair of novel meroterpenoid enantiomers featuring an unprecedented dioxaspirocyclic skeleton constructed from a 6/6/6/6 tetracyclic system and an unusual tricyclo­[4.3.3.0<sup>3′,7′</sup>]­dodecane motif, were isolated from <i>Ganoderma applanatum</i>. Its structure and absolute configurations were determined by spectroscopic analyses, X-ray crystallography, and ECD (electronic circular dichroism calculations). A plausible biogenetic pathway, involving a key Gomberg–Bachmann reaction, was also proposed for (±)-<b>1</b>. Biological studies showed that (±)-<b>1</b> and its enantiomers exhibited different inhibitory activities on T-type voltage-gated calcium channels. dodecane;motif;Ganoapplanin;Biological studies;Ganoderma applanatum;dioxaspirocyclic skeleton;dichroism calculations;spectroscopic analyses;Polycyclic Meroterpenoid Enantiomers;Gomberg;novel meroterpenoid enantiomers;T-type voltage-gated calcium channels;biogenetic pathway;ECD;X-ray crystallography;configuration;tricyclo;tetracyclic 2016-11-18
    https://acs.figshare.com/articles/dataset/_-Ganoapplanin_a_Pair_of_Polycyclic_Meroterpenoid_Enantiomers_from_i_Ganoderma_applanatum_i_/4240016
10.1021/acs.orglett.6b03064.s001