Synthesis of Polycarbonyl Pyrroles via K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>‑Mediated Oxidative Cyclization of Enamines Peng Gao Juan Wang Zi-Jing Bai Li Shen Yun-Yun Yan De-Suo Yang Ming-Jin Fan Zheng-Hui Guan 10.1021/acs.orglett.6b03060.s001 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Polycarbonyl_Pyrroles_via_K_sub_2_sub_S_sub_2_sub_O_sub_8_sub_Mediated_Oxidative_Cyclization_of_Enamines/4233941 A novel K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-promoted oxidative cyclization of enamines is described. A variety of enamines having diverse functional groups and substitution patterns react well using K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> as the oxidant in the absence of catalyst. This protocol provides a very simple route for the synthesis of polycarbonyl pyrroles and has the advantages of readily available starting materials, mild reaction conditions, and a wide scope of substrates. 2016-11-15 20:04:33 enamine Polycarbonyl Pyrroles Cyclization reaction conditions Mediated substitution patterns oxidative cyclization variety novel K 2 S 2 O 8 absence Oxidative Synthesi polycarbonyl pyrroles K 2 S 2 O 8 material catalyst oxidant Enamine substrate synthesis scope