Synthesis of Polycarbonyl Pyrroles via K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>‑Mediated Oxidative Cyclization
of Enamines
Peng Gao
Juan Wang
Zi-Jing Bai
Li Shen
Yun-Yun Yan
De-Suo Yang
Ming-Jin Fan
Zheng-Hui Guan
10.1021/acs.orglett.6b03060.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Polycarbonyl_Pyrroles_via_K_sub_2_sub_S_sub_2_sub_O_sub_8_sub_Mediated_Oxidative_Cyclization_of_Enamines/4233941
A novel K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-promoted oxidative
cyclization of enamines is described. A variety of enamines having
diverse functional groups and substitution patterns react well using
K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> as the oxidant in the absence
of catalyst. This protocol provides a very simple route for the synthesis
of polycarbonyl pyrroles and has the advantages of readily available
starting materials, mild reaction conditions, and a wide scope of
substrates.
2016-11-15 20:04:33
enamine
Polycarbonyl Pyrroles
Cyclization
reaction conditions
Mediated
substitution patterns
oxidative cyclization
variety
novel K 2 S 2 O 8
absence
Oxidative
Synthesi
polycarbonyl pyrroles
K 2 S 2 O 8
material
catalyst
oxidant
Enamine
substrate
synthesis
scope