One-Pot Microwave Synthesis of Water-Dispersible,
High Fluorescence Silicon
Nanoparticles and Their Imaging Applications in Vitro and in Vivo
Hong-Li Ye
Shi-Jiao Cai
Si Li
Xi-Wen He
Wen-You Li
Yu-Hao Li
Yu-Kui Zhang
10.1021/acs.analchem.6b03209.s001
https://acs.figshare.com/articles/journal_contribution/One-Pot_Microwave_Synthesis_of_Water-Dispersible_High_Fluorescence_Silicon_Nanoparticles_and_Their_Imaging_Applications_in_Vitro_and_in_Vivo/4232672
Silicon nanoparticles (SiNPs) have
been reported to be synthesized
by microwave-assisted methods under high pressure. However, there
is still a lack of knowledge about the synthesis of SiNPs via microwave-assisted
methods under normal pressure. Here we developed a new, facile, one-pot
microwave-assisted method for the synthesis SiNPs (∼4.2 nm)
with excellent water solubility under normal pressure by employing
glycerol as the solvent. Furthermore, glycerol might be responsible
for the photoluminescence quantum yield (PLQY) value up to 47% for
the resultant SiNPs. The use of organic solvent could afford less
nanoparticle surface defects compared with those prepared in aqueous
solution, thus improving the fluorescent efficiency. The as-prepared
SiNPs simultaneously featured bright blue-green fluorescence, long
lifetime (∼12.8 ns), obvious up-conversion luminescence originating
from two-photon absorption, superbly strong photostability, and favorable
low toxicity. As a satisfactory probe, the as-synthesized SiNPs were
successfully applied in fluorescence imaging of human cervical carcinoma
cell lines (HeLa) and zebrafish.
2016-10-31 00:00:00
microwave-assisted methods
carcinoma cell lines
PLQY
nanoparticle surface defects
Vivo Silicon nanoparticles
One-Pot Microwave Synthesis
High Fluorescence Silicon Nanoparticles
SiNP
one-pot microwave-assisted method