%0 Journal Article %A Anandhan, Ramasamy %A Kannan, Ayyavoo %A Rajakumar, Perumal %D 2017 %T Synthesis and anti-inflammatory activity of triazole-based macrocyclic amides through click chemistry %U https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_Anti-Inflammatory_Activity_of_Triazole_Based_Macrocyclic_Amides_through_Click_Chemistry/4207020 %R 10.6084/m9.figshare.4207020.v2 %2 https://ndownloader.figshare.com/files/6864609 %K Anti-inflammatory %K click chemistry %K macrocyclic amides %K NSAIDs %X

Triazole-based macrocyclic amides 1–12 with amide group as the intrannular functionality has been synthesized through click chemistry. Triazole-based macrocyclic amides 112 show good anti-inflammatory activity even at low concentration (50 µg/mL) when compared to that of the reference drug prednisolone. BINOL-based chiral macrocyclic amides and pyridine-based macrocyclic amides show better anti-inflammatory activity than the other synthesized macrocyclic amides.

%I Taylor & Francis