Supplementary Material for: Impact of Cognitive Function Change on Mortality in Renal Transplant and End-Stage Renal Disease Patients
Sharma A.
Yabes J.
Al Mawed S.
Wu C.
Stilley C.
Unruh M.
Jhamb M.
10.6084/m9.figshare.4143714.v1
https://karger.figshare.com/articles/figure/Supplementary_Material_for_Impact_of_Cognitive_Function_Change_on_Mortality_in_Renal_Transplant_and_End-Stage_Renal_Disease_Patients/4143714
<i>Background:</i> Limited evidence from small-scale studies, mainly involving end-stage renal disease (ESRD) patients, suggests that kidney transplantation may improve cognitive function. We examined changes in cognitive function after a kidney transplant and its association with survival in advanced chronic kidney disease (CKD)/ESRD patients. <i>Methods:</i> In a prospective study design, cognitive performance of 90 patients (50.6 ± 13.1 years, 66.7% men, 27.8% blacks, 76% CKD stages 4-5) was assessed at the respective patients' residences using established neurocognitive tests. <i>Results:</i> Among the 90 patients, 44 received a kidney transplant (KTx group) while 46 did not (no-KTx group). After a mean follow-up of ∼19 months, there was no significant change in scores for majority of cognitive tests in either group. Older age, but not diabetes or renal function status (CKD vs. ESRD), was a determinant of poor follow-up cognitive performance. Additionally, poor attention/psychomotor speed and executive performance (as measured by Trails A and Stroop test, respectively) was associated with higher mortality over a mean follow-up of 4.7 years, even after adjustment for age, sex, diabetes, CKD or ESRD status and kidney transplant status. <i>Conclusion:</i> Overall, cognitive function does not significantly improve after kidney transplant or significantly decline in non-transplanted, advanced CKD/ESRD patients. Poor attention, psychomotor speed and executive performance independent of transplant status were associated with higher mortality over time.
2016-11-01 07:36:32
Kidney transplant
Cognitive function
Mortality