TY - DATA T1 - Dual role of CDK1 in tumorigenesis and chemotherapeutic sensitivity. PY - 2011/08/24 AU - Chunyu Zhang AU - Abdel G. Elkahloun AU - Matthew Robertson AU - Joell J. Gills AU - Junji Tsurutani AU - Joanna H. Shih AU - Junya Fukuoka AU - M. Christine Hollander AU - Curtis C. Harris AU - William D. Travis AU - Jin Jen AU - Phillip A. Dennis UR - https://plos.figshare.com/articles/figure/_Dual_role_of_CDK1_in_tumorigenesis_and_chemotherapeutic_sensitivity_/414190 DO - 10.1371/journal.pone.0023849.g007 L4 - https://ndownloader.figshare.com/files/743824 KW - cdk1 KW - tumorigenesis KW - chemotherapeutic N2 - A. A model of CDK1 activation. When inactive p-Y15/T14 CDK1 is dephosphorylated on Y15 and T14 by CDC25A, it associates with Cyclin A/B and becomes active within the cytoplasm, then quickly translocates into the nucleus, where it promotes G1 to S and G2/M transitions. Active CDK1 is inactivated via sequential phosphorylation of Y15 and T14 by Wee1 and Myt1, and sequestrated by 14-3-3σ in the cytoplasm. This process repeats with cell cycling to drive cellular proliferation. B. A diagram to illustrate the dual role of CDK1 as a tumorigenic driver in lung carcinogenesis and a sensitizer in chemotherapeutic responsiveness. ER -