10.1021/acs.joc.6b01837.s008 Jing-Kai Huang Jing-Kai Huang Ying-Chieh Wong Ying-Chieh Wong Tzu-Ting Kao Tzu-Ting Kao Chen-Tso Tseng Chen-Tso Tseng Kak-Shan Shia Kak-Shan Shia Cobalt(II)-Catalyzed Aerobic Oxidation of Terminal-Capped Alkynyl α‑Cyano Alkanone Systems. An Oxygen-Mediated Radical Chain Reaction American Chemical Society 2016 sequence Aerobic dehydration manner Alkynyl NHPI Cyano mechanistically Oxidation cyclization 5- exo methodology α- hydrogen abstraction hydrogen transfer oxidation Terminal-Capped silyl alkyl-capped alkynyl α- cyano alkanone systems Alkanone novel chain reaction Cobalt functionalized products yield aryl hydroxyphthalimide Oxygen-Mediated Radical Chain Reaction 2016-10-17 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Cobalt_II_-Catalyzed_Aerobic_Oxidation_of_Terminal-Capped_Alkynyl_Cyano_Alkanone_Systems_An_Oxygen-Mediated_Radical_Chain_Reaction/4057008 A new <i>N</i>-hydroxyphthalimide (NHPI)/Co­(II)-catalyzed protocol, mechanistically involving a sequence of α-hydrogen abstraction, 5-<i>exo</i>-<i>dig</i> cyclization, oxygen capture, hydrogen transfer, and 1,4-dehydration, has been developed to facilitate aerobic oxidation of aryl-, silyl-, and alkyl-capped alkynyl α-cyano alkanone systems to the corresponding highly functionalized products in an effective manner, thus turning this novel chain reaction, originally occurring spontaneously in low yields, into a practical methodology.