TY - DATA T1 - Diacyl Disulfide: A Reagent for Chemoselective Acylation of Phenols Enabled by 4‑(N,N‑Dimethylamino)pyridine Catalysis PY - 2016/10/21 AU - Hong-Xin Liu AU - Ya-Qian Dang AU - Yun-Fei Yuan AU - Zhi-Fang Xu AU - Sheng-Xiang Qiu AU - Hai-Bo Tan UR - https://acs.figshare.com/articles/journal_contribution/Diacyl_Disulfide_A_Reagent_for_Chemoselective_Acylation_of_Phenols_Enabled_by_4_i_N_i_i_N_i_Dimethylamino_pyridine_Catalysis/4047603 DO - 10.1021/acs.orglett.6b02818.s001 L4 - https://ndownloader.figshare.com/files/6517233 KW - site-selective acylation KW - platform KW - dimethylamino KW - Diacyl Disulfide KW - diacyl disulfide KW - Catalysi KW - realm KW - catalysi KW - Reagent KW - moisture tolerance KW - group chemistry KW - Chemoselective Acylation KW - phenolic KW - acylation reagent KW - DMAP KW - ester formation KW - importance KW - Phenols Enabled KW - product modification KW - efficiency KW - Dimethylamino KW - aliphatic hydroxyl groups N2 - A general and excellent acylation reagent, diacyl disulfide, was uncovered for efficient ester formation enabled by DMAP (4-(N,N-dimethylamino)­pyridine) catalysis. This protocol offered a promising synthetic platform on site-selective acylation of phenolic and primary aliphatic hydroxyl groups, which greatly expanded the realm of protecting group chemistry. The importance of the reagent was also reflected by its excellent moisture tolerance, high efficiency, and potential in synthetic chemistry and biologically meaningful natural product modification. ER -