TY - DATA T1 - The relationship of salivary testosterone and male sexual dysfunction in opioid-associated androgen deficiency (OPIAD) PY - 2016/10/18 AU - Raquel Ajo AU - Ana Segura AU - Laura Mira AU - María-del-Mar Inda AU - Rocío Alfayate AU - Angel Sánchez-Barbie AU - César Margarit AU - Ana M. Peiró UR - https://tandf.figshare.com/articles/journal_contribution/The_relationship_of_salivary_testosterone_and_male_sexual_dysfunction_in_opioid-associated_androgen_deficiency_OPIAD_/4037685 DO - 10.6084/m9.figshare.4037685.v1 L4 - https://ndownloader.figshare.com/files/6500745 KW - Salivary testosterone KW - sexual dysfunction KW - erectile dysfunction KW - opioids KW - chronic pain KW - OPIAD N2 - Background: Opioids are an effective treatment for chronic non-malignant pain (CNP). Long-term use risks and side effects such as opioid-induced androgen deficiency (OPIAD) exist. This could be measured by saliva testosterone (Sal-T). Objectives: To evaluate OPIAD in long-term opioid use in CNP patients. Methods: A cross-sectional study included CNP male outpatients under opioid treatment. Total-Testosterone (Total-T), Free-Testosterone (Free-T), Bio-Testosterone (Bio-T) and Sal-T were measured. Correlations were calculated by Spearman’s rho (SPSS 20). Results: From 2012 to 2014, 134 from 249 (54%) consecutive male outpatients reported erectile dysfunction (ED), 37% of them related to opioids and 19% evidenced OPIAD. A total of 120 subjects (94 cases and 26 matched-controls) were included. A significantly lower luteinizing hormone, Total-T and Free-T were found, as well as, a significant correlation between Sal-T and Total-T (r = 0.234, p = 0.039), Bio-T (r = 0.241, p = 0.039), IIEF (r = 0.363, p = 0.003) and HAD-anxiety (r = −0.414, p = 0.012) in OPIAD patients. Sal-T levels were significantly lower in patients with severe–moderate ED versus mild ED (p = 0.045) and in patients with severe ED versus moderate–mild ED (p = 0.036). Conclusions: These data demonstrate the high prevalence of ED in long-term use of opioids, part of this is associated to OPIAD, which can be tested by Sal-T as a non-invasive approach. ER -