Reyer, Henry Ponsuksili, Siriluck Kanitz, Ellen Pöhland, Ralf Wimmers, Klaus Murani, Eduard Stereogram of the interaction between glucocorticoid receptor ligand binding domain and dexamethasone. <p>Structural models of helix 3 to helix 7 of the ligand binding domain of the wild-type Ala610 (A) and the mutated Val610 (B) receptor variants are shown. The distances of the alternative alanine (blue) and valine (red) residue at amino acid position 610 with the two methyl carbon atoms of Val654, and the carbon C-6 and C-7 positions of the ligand dexamethasone (green), are indicated in angstroms (Å).</p> GR responsiveness;receptor-ligand interactions;GR-binding studies;Ligand Binding Domain;ligand binding;gain-of-function substitution;Val 610 GR;binding distances;Helix 5;Ala 610Val substitution;HPA axis activity;cortisol production;receptor-ligand interaction;glucocorticoid receptor;GR ligands;neuroendocrine stress response;trait locus;Glucocorticoid Receptor Enhances Receptor-Ligand Interaction;mediates feedback regulation;non-glucocorticoid steroids;Natural Mutation;protein structure prediction;phenotypic effects;Ala 610Val;ligand binding pocket;ligand binding domain 2016-10-13
    https://plos.figshare.com/articles/figure/Stereogram_of_the_interaction_between_glucocorticoid_receptor_ligand_binding_domain_and_dexamethasone_/4031325
10.1371/journal.pone.0164628.g003