10.1371/journal.pgen.1006339.g003 Celia Payen Celia Payen Anna B. Sunshine Anna B. Sunshine Giang T. Ong Giang T. Ong Jamie L. Pogachar Jamie L. Pogachar Wei Zhao Wei Zhao Maitreya J. Dunham Maitreya J. Dunham Recurrently mutated genes reveal how evolution is constrained. Public Library of Science 2016 nutrient-limited conditions sulfate-limited condition mutation high-affinity sulfate transporter fitness effects Evolved Yeast Populations High-throughput sequencing 2016-10-11 17:38:02 Figure https://plos.figshare.com/articles/figure/Recurrently_mutated_genes_reveal_how_evolution_is_constrained_/4012152 <p>(<b>A</b>) Repeatability of adaptation and parallelism at the gene level. Genes were classified by the number of mutations detected during Evolve and Resequence studies: 154 genes were mutated in more than one sample; 48 genes with recurrent mutations were mutated in more than one condition (small panel). (<b>B</b>) Enrichment of recurrently mutated genes with high-impact mutations compared with genes mutated in only one sample. Enrichment is not observed for moderate or low impact mutations, or modifiers. Error bars are 95% CIs.</p>