TY - DATA T1 - Convenient and efficient method for the synthesis of substituted quinolines via one-pot heteroannulation reaction of o-amino arylketones with α-methylene ketones under solvent-free conditions PY - 2016/11/16 AU - G. Vanajatha AU - V. Prabhakar Reddy UR - https://tandf.figshare.com/articles/journal_contribution/Convenient_and_Efficient_Method_for_the_Synthesis_of_Substituted_Quinolines_i_via_i_One-Pot_Hetero-Annulation_Reaction_of_i_o_i_-amino_Arylketones_with_-methylene_Ketones_Under_Solvent-Free_Conditions/4001274 DO - 10.6084/m9.figshare.4001274.v2 L4 - https://ndownloader.figshare.com/files/6414240 KW - Friedländer annulation KW - α-Methylene ketones KW - o-aminoaryl ketones KW - solvent-free conditions KW - substituted quinolines KW - tetrabutylammonium peroxydisulfate N2 - A facile and practical approach to the synthesis of a wide range of functionalized quinolines was developed via a tandem heteroannulation reaction of o-aminoarylketones with diverse α-methylene ketones in high yields by using tetrabutylammonium peroxydisulfate as a versatile reagent (25 mol%) at ambient temperature under solvent-free conditions. This protocol was applied to the synthesis of drug-like molecules, which are key intermediates of alkaloid camptothecin. ER -