Hosono, Kanako Isonaka, Risa Kawakami, Tadashi Narumiya, Shuh Majima, Masataka Reduction in the recruitment of M2 macrophages in wound granulation tissues by a COX-2 inhibitor. <p>(A–D) Real-time PCR analyses of the expression levels of the <i>IL-1β</i> (A), <i>iNOS</i> (B), <i>MR</i> (C), and <i>Ang-1</i>(D) mRNAs in day 3 granulation tissues from mice treated with or without celecoxib (100 mg/kg). Data are expressed as the mean ± SEM (n = 6). *<i>P</i> < 0.05. (E, F) The left panels show representative images of CD11b (green) (E, F) and IL-1β (red) (E) or MR (red) (F) in immunostained day 3 wound granulation tissues from mice treated with or without celecoxib (100 mg/kg). Scale bars: 10 μm. The data are quantified in the right panel. Data are expressed as the mean ± SEM (n = 6). ***<i>P</i> < 0.001.</p> VEGF receptor -3.;prostaglandin E 2;COX -2 inhibition;Prostaglandin E Receptors;EP 3;EP 4;recruitment;CD 11b macrophages;COX -2 inhibitor;EP knockout mice;metal ear punch;prostaglandin E synthase -1. Administration;PGE 2 stimulation;VEGF-C;VEGF-D;lymphangiogenesi;granulation tissues;C 57BL mice;EP 4 Facilitates Wound Healing;M 2 macrophages;EP receptor agonists;COX -2;M 2 Macrophages;Lymphangiogenesi;wound healing processes 2016-10-06
    https://plos.figshare.com/articles/figure/Reduction_in_the_recruitment_of_M2_macrophages_in_wound_granulation_tissues_by_a_COX-2_inhibitor_/3999270
10.1371/journal.pone.0162532.g005