Novel coumarin isoxazoline derivatives: Synthesis and study of antibacterial activities
Garbapu Suresh
Ratnakaram Venkata Nadh
Navuluri Srinivasu
Kishore Kaushal
10.6084/m9.figshare.3997437
https://tandf.figshare.com/articles/journal_contribution/Novel_Coumarin_Isoxazoline_Derivatives_Synthesis_and_Study_of_Antibaterial_Activities/3997437
<p>A highly efficient and mild protocol for the syntheses of ethyl-3-[7-benzyloxy-4-methyl-2-oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-isoxazole carboxylates and ethyl-3-[7-benzyloxy-3-chloro-4-methyl-2-oxo-2H-8-chromenyl]-5-aryl-4,5-dihydro-4-isoxazole carboxylates in good yields via [3 + 2] cycloaddition of in situ–generated nitrile oxides from 7-benzyloxy-4-methyl-coumarin hydroxymoylchlorides and 7-benzyloxy-3-chloro-4-methyl-coumarin hydroxymoylchlorides respectively with ethyl-3-aryl prop-2-enoate has been developed. The new compounds are screened for antibacterial activity.</p>
2016-12-05 15:48:06
Antibacterial activity
coumarin isoxazoline
[3 + 2] cycloaddition
1,3-dipolar cycloaddition
hydroximoyl chloride
nitrile oxide