10.1021/acsami.6b05514.s001
Xiyu Li
Xiyu
Li
Haifeng Chen
Haifeng
Chen
Yb<sup>3+</sup>/Ho<sup>3+</sup> Co-Doped Apatite Upconversion
Nanoparticles to Distinguish Implanted Material from Bone Tissue
American Chemical Society
2016
Yb
material image
chemical technique
novel strategy
upconversion emissions
tissue image
Ho
hydroxyl channel
bone tissue
bone regeneration
dopant concentrations
HA
lattice models
material-tissue distribution
hydrothermal synthesis
bone reconstruction
lattice structure
Distinguish Implanted Material
vivo samples
FA
Bone Tissue
discriminable fluorescence
fluorine channel
upconversion apatite particles
980 nm near-infrared excitation
image superposition method
emission behavior
apatite crystal structure
histological sections
2016-09-27 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Yb_sup_3_sup_Ho_sup_3_sup_Co-Doped_Apatite_Upconversion_Nanoparticles_to_Distinguish_Implanted_Material_from_Bone_Tissue/3996855
The exploration of bone reconstruction
with time requires the combination
of a biological method and a chemical technique. Lanthanide Yb<sup>3+</sup> and Ho<sup>3+</sup> co-doped fluorapatite (FA:Yb<sup>3+</sup>/Ho<sup>3+</sup>) and hydroxyapatite (HA:Yb<sup>3+</sup>/Ho<sup>3+</sup>) particles with varying dopant concentrations were prepared by hydrothermal
synthesis and thermal activation. Controllable green and red upconversion
emissions were generated under 980 nm near-infrared excitation; the
FA:Yb<sup>3+</sup>/Ho<sup>3+</sup> particles resulted in superior
green luminescence, while HA:Yb<sup>3+</sup>/Ho<sup>3+</sup> dominated
in red emission. The difference in the green and red emission behavior
was dependent on the lattice structure and composition. Two possible
lattice models were proposed for Yb<sup>3+</sup>/Ho<sup>3+</sup> co-doped
HA and FA along the hydroxyl channel and fluorine channel of the apatite
crystal structure. We first reported the use of the upconversion apatite
particles to clearly distinguish implanted material from bone tissue
on stained histological sections of harvested in vivo samples. The
superposition of the tissue image and material image is a creative
method to show the material-tissue distribution and interrelation.
The upconversion apatite particles and image superposition method
provide a novel strategy for long-term discriminable fluorescence
tracking of implanted material or scaffold during bone regeneration.