TY - DATA T1 - Supplementary Material for: Frequency and Determinants of Adherence to Oral Anticoagulants in Stroke Patients with Atrial Fibrillation in Clinical Practice PY - 2016/10/05 AU - Polymeris A.A. AU - Traenka C. AU - Hert L. AU - Seiffge D.J. AU - Peters N. AU - De Marchis G.M. AU - Bonati L.H. AU - Lyrer P.A. AU - Engelter S.T. UR - https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Frequency_and_Determinants_of_Adherence_to_Oral_Anticoagulants_in_Stroke_Patients_with_Atrial_Fibrillation_in_Clinical_Practice/3985230 DO - 10.6084/m9.figshare.3985230.v1 L4 - https://ndownloader.figshare.com/files/6329073 KW - Atrial fibrillation KW - Stroke KW - Non-vitamin K antagonist oral anticoagulants KW - Adherence KW - Self-report KW - Determinants N2 - Background: Vitamin K antagonists (VKAs) and non-VKA oral anticoagulants (NOACs) are beneficial in patients with stroke and atrial fibrillation (AF). However, little is known about frequency and determinants of adherence to NOACs/VKAs in clinical practice. Methods: This is a single-center explorative study from the Novel Oral Anticoagulants in Stroke Patients (NOACISP)-LONGTERM registry. We included consecutive AF-stroke patients treated with NOACs/VKAs and followed up for 3-24 months. Adherence was assessed at follow-up using structured interviews and quantified as the proportion of prescribed doses taken (PDT). Outcome measures were (i) full adherence, (ii) ≥95% adherence and (iii) ≥80% adherence (i.e., PDT 100/≥95/≥80%). To explore determinants of full adherence, we compared characteristics of fully and non-fully adherent patients. Results: A total of 218 of 251 (86.9%) patients (48% female, mean age 77.9 ± 9.1 years, 78% NOACs; 22% VKAs) were eligible for analysis with a median follow-up of 12 months: fully adherent were 78.4% patients (NOACs 77.1%, VKAs 83.3%, p = 0.35), ≥95% adherent were 95.4% and ≥80% adherent were 97.2%. Fully adherent patients took more pills daily (median (interquartile range) 7 (5-10) vs. 6 (4-8), p = 0.039), had more often previous antithrombotic treatment (70.8 vs. 53.2%, p = 0.023), caregiver-assisted medication administration (54.2 vs. 19.1%, p < 0.001) and functional dependency (32.8 vs. 15%, p = 0.011) than non-fully adherent patients. Conclusions: Full adherence was frequent. Patients naïve to antithrombotics, taking few pills, which they self-administer, were at the highest risk of non-adherence and may benefit most from adherence-enhancing interventions. ER -