10.1371/journal.pgen.1005938.g002
Sabrina L. Andersen
Sabrina
L. Andersen
Aimee Zhang
Aimee
Zhang
Margaret Dominska
Margaret
Dominska
María Moriel-Carretero
María
Moriel-Carretero
Emilia Herrera-Moyano
Emilia
Herrera-Moyano
Andrés Aguilera
Andrés
Aguilera
Thomas D. Petes
Thomas
D. Petes
Crossovers and associated gene conversion events in red/white sectored colonies.
Public Library of Science
2016
chromatid
XPD
DSCB
rad 3 strains
2AX
SCB
HXT 11 genes
wild-type cells
Homologous Recombination Events
NER
Saccharomyces cerevisae RAD 3 gene
mitotic recombination events
DSB
IMA
XV
mitotic recombination
216 unselected genomic alterations
single-stranded DNA gaps
crossover
recombinogenic double-strand breaks
nucleotide excision repair
recombination events
hyper-Rec phenotype
rad 3-101
rad 3-102
TFIIH
rad 3 Hyper-Recombination Mutants
2016-03-11 01:01:02
Figure
https://plos.figshare.com/articles/figure/Crossovers_and_associated_gene_conversion_events_in_red_white_sectored_colonies_/3965901
<p>In the figure, duplicated YJM789- and W303-1A-derived chromatids are shown as black and red lines, respectively. Centromeres are shown as ovals, and crossovers as X's. Short horizontal arrows indicate the site of the recombinogenic DNA lesion. At the bottom of each diagram, we show a pair of lines that depict patterns of LOH. The top and bottom lines summarize LOH patterns in the red and white sectors, respectively, using the following code: green (heterozygous SNPs), red (homozygous W303-1A-derived SNPs), and black (homozygous YJM789-derived SNPs). The boxed regions show gene conversion events as discussed in the text. A. Crossover unassociated with gene conversion. B. Crossover associated with the repair of one broken chromatid, generating a 3:1 conversion event. The region of the conversion is boxed. C. Crossover associated with the repair of two sister chromatids broken at the same position. The repair of one chromatid is associated with a crossover. If the sizes of the conversion tracts are the same for both broken chromatids, a 4:0 conversion event would be produced. D. Crossover associated with the repair of two broken sister chromatids for which the conversion tracts were of different sizes. The net result is a 4:0/3:1 hybrid conversion tract.</p>