%0 Figure %A Zurek, Magdalena %A Sladen, Louise %A Johansson, Edvin %A Olsson, Marita %A Jackson, Sonya %A Zhang, Hui %A Mayer, Gaell %A D. Hockings, Paul %D 2016 %T Representative TI = 6000 ms image, lung density (S0air), R1air, R1O2 maps of a control and PPE-challenged mouse lung. %U https://plos.figshare.com/articles/figure/Representative_TI_6000_ms_image_lung_density_S0_sub_air_sub_R1_sub_air_sub_R1_sub_O2_sub_maps_of_a_control_and_PPE-challenged_mouse_lung_/3961278 %R 10.1371/journal.pone.0151211.g001 %2 https://ndownloader.figshare.com/files/6193218 %K MRI %K lung function %K lung density %K oxygen delivery %K OE-MRI %K resonance imaging method %K oxygen uptake %K region %K relaxation time indices %K ultrashort echo-time imaging sequence %K C 57BL mice %K porcine pancreatic elastase %K Principal Findings PPE-challenged mice %K PPE-challenged animals %X

The maps are overlaid on TI = 6000 ms image acquired when animals were breathing air (a). ΔR1 (oxygen uptake), ΔR2* (oxygen delivery) maps for the same control and a PPE-challenged mouse (b). The challenged mouse exhibits less uniform distributions of ΔR1 and ΔR2* suggesting that the oxygen uptake and delivery to the lung were more heterogeneous. Regions of spatially matched ΔR1 and ΔR2* are indicated by arrows. Mean ΔR1 assessed in 20 bins based on ΔR2* for control (open squares) and PPE-challenged (filled squares) mice, showing excellent correlation between ΔR1 and ΔR2* (c).

%I PLOS ONE