Representative TI = 6000 ms image, lung density (S0<sub>air</sub>), R1<sub>air</sub>, R1<sub>O2</sub> maps of a control and PPE-challenged mouse lung. Magdalena Zurek Louise Sladen Edvin Johansson Marita Olsson Sonya Jackson Hui Zhang Gaell Mayer Paul D. Hockings 10.1371/journal.pone.0151211.g001 https://plos.figshare.com/articles/figure/Representative_TI_6000_ms_image_lung_density_S0_sub_air_sub_R1_sub_air_sub_R1_sub_O2_sub_maps_of_a_control_and_PPE-challenged_mouse_lung_/3961278 <p>The maps are overlaid on TI = 6000 ms image acquired when animals were breathing air (a). ΔR1 (oxygen uptake), ΔR2* (oxygen delivery) maps for the same control and a PPE-challenged mouse (b). The challenged mouse exhibits less uniform distributions of ΔR1 and ΔR2* suggesting that the oxygen uptake and delivery to the lung were more heterogeneous. Regions of spatially matched ΔR1 and ΔR2* are indicated by arrows. Mean ΔR1 assessed in 20 bins based on ΔR2* for control (open squares) and PPE-challenged (filled squares) mice, showing excellent correlation between ΔR1 and ΔR2* (c).</p> 2016-03-15 00:25:18 MRI lung function lung density oxygen delivery OE-MRI resonance imaging method oxygen uptake region relaxation time indices ultrashort echo-time imaging sequence C 57BL mice porcine pancreatic elastase Principal Findings PPE-challenged mice PPE-challenged animals