A model for key LIC2 functions in SAC silencing during mitosis. Sagar P. Mahale Amit Sharma Sivaram V. S. Mylavarapu 10.1371/journal.pone.0159646.g008 https://plos.figshare.com/articles/figure/A_model_for_key_LIC2_functions_in_SAC_silencing_during_mitosis_/3886299 <p>Novel functions of mitotic LIC2 uncovered from this study in silencing the spindle assembly checkpoint (SAC) are shown. LIC2-dynein strips attachment sensing SAC proteins (Mad1, Mad2, Zw10) from metaphase kinetochores, like LIC1-dynein. LIC2-dynein has the additional capability of causing removal of tension-sensing SAC protein BubR1, which is lacking in LIC1-dynein. The model offers a possible mechanistic explanation for the differential effects of the two LICs in mediating metaphase to anaphase progression.</p> 2016-07-21 13:37:48 motor cytoplasmic dynein SAC eukaryotic cell division Dynein Light Intermediate Chain 2 Facilitates cytoplasmic dynein LIC 1 LIC 2 tension-sensing checkpoint proteins LIC 2 depletion kinetochore-microtubule attachment-sensing arm homolog LIC 1. dynein Light Intermediate Chain homologs Quantitative fluorescence microscopy LIC 2 subunit Spindle Assembly Checkpoint cytoplasmic dynein complexes mitotic checkpoint inactivation spindle assembly checkpoint