A model for key LIC2 functions in SAC silencing during mitosis.
Sagar P. Mahale
Amit Sharma
Sivaram V. S. Mylavarapu
10.1371/journal.pone.0159646.g008
https://plos.figshare.com/articles/figure/A_model_for_key_LIC2_functions_in_SAC_silencing_during_mitosis_/3886299
<p>Novel functions of mitotic LIC2 uncovered from this study in silencing the spindle assembly checkpoint (SAC) are shown. LIC2-dynein strips attachment sensing SAC proteins (Mad1, Mad2, Zw10) from metaphase kinetochores, like LIC1-dynein. LIC2-dynein has the additional capability of causing removal of tension-sensing SAC protein BubR1, which is lacking in LIC1-dynein. The model offers a possible mechanistic explanation for the differential effects of the two LICs in mediating metaphase to anaphase progression.</p>
2016-07-21 13:37:48
motor cytoplasmic dynein
SAC
eukaryotic cell division
Dynein Light Intermediate Chain 2 Facilitates
cytoplasmic dynein
LIC 1
LIC 2
tension-sensing checkpoint proteins
LIC 2 depletion
kinetochore-microtubule attachment-sensing arm
homolog LIC 1.
dynein Light Intermediate Chain homologs
Quantitative fluorescence microscopy
LIC 2 subunit
Spindle Assembly Checkpoint
cytoplasmic dynein complexes
mitotic checkpoint inactivation
spindle assembly checkpoint