10.1371/journal.pone.0160074.g006
Valentina Masola
Valentina
Masola
Gianluigi Zaza
Gianluigi
Zaza
Giovanni Gambaro
Giovanni
Gambaro
Maurizio Onisto
Maurizio
Onisto
Gloria Bellin
Gloria
Bellin
Gisella Vischini
Gisella
Vischini
Iyad Khamaysi
Iyad
Khamaysi
Ahmad Hassan
Ahmad
Hassan
Shadi Hamoud
Shadi
Hamoud
Omri Nativ
Omri
Nativ
Samuel N. Heyman
Samuel N.
Heyman
Antonio Lupo
Antonio
Lupo
Israel Vlodavsky
Israel
Vlodavsky
Zaid Abassi
Zaid
Abassi
<i>In vivo</i> Heparanase (HPSE) expression induced by Ischemia and Reperfusion (I/R) kidney injury.
Public Library of Science
2016
FGF -2
graft function
histological methodologies
mesenchymal transition
VIM
30 min
WT littermates
vivo models
TGF β-induced EMT
FN
WT animals
HPA-tg mice
72 h
Potential New Factor
SMA
EMT markers
pro-fibrotic machinery
Renal Epithelial Mesenchymal Transition
Methods Wild type
mice over-expressing HPSE
SST 0001 treatment
WT cells
disease progression
2016-07-28 12:26:44
Figure
https://plos.figshare.com/articles/figure/_i_In_vivo_i_Heparanase_HPSE_expression_induced_by_Ischemia_and_Reperfusion_I_R_kidney_injury_/3877980
<p><b>A)</b> Box plot representing relative gene expression of HPSE evaluated by real-time PCR in renal tissue extract from Wild type (WT) mice. Results were normalized to GAPDH expression. Mean ± S.E (error bars) of two separate experiments performed in triplicate. <b>B)</b> Representative immunofluorescence staining for HPSE in cortical renal tissues of WT mice 72 h after sham operation or I/R kidney injury. I/R, ischemia/reperfusion. <b>C)</b> Quantification of the immunofluorescence staining. **p<0.001vs. WT SHAM.</p>