10.1371/journal.pntd.0005015.g005 Yan Fu Yan Fu Andreas L. Chryssafidis Andreas L. Chryssafidis John A. Browne John A. Browne Jack O'Sullivan Jack O'Sullivan Paul A. McGettigan Paul A. McGettigan Grace Mulcahy Grace Mulcahy Production of nitric oxide in macrophages. Public Library of Science 2016 hepatica infection vivo study mechanisms underpinning ovine PBMC DEGS gene expression changes livestock farming food-borne zoonotic agent novel information Transcriptomic Study Several transcriptional regulators Potential mechanisms control strategies miR 155-5p Signaling TLR Nitric Oxide transcriptomic analysis Ingenuity Pathway Analysis Fasciola hepatica Infection Background Fasciola hepatica IL 18 IL 12 TGF Ovine Immune Responses response immune-associated pathways 2016-09-23 17:37:22 Figure https://plos.figshare.com/articles/figure/Production_of_nitric_oxide_in_macrophages_/3857595 <p>This pathway is represented with gene expression (log2 fold-change) values overlaid. Red shading indicates increased expression in PBMCs at T2 compared to T1. Green shading indicates decreased expression in PBMCs at T2 compared to T1. Color intensity indicates expression level. White and grey shading indicates not significantly differentially expressed and filtered out due to low expression, respectively.</p>