10.6084/m9.figshare.3847500.v1
Anna Dzieża-Grudnik
Anna
Dzieża-Grudnik
Joanna Sulicka
Joanna
Sulicka
Magdalena Strach
Magdalena
Strach
Olga Siga
Olga
Siga
Ewa Klimek
Ewa
Klimek
Mariusz Korkosz
Mariusz
Korkosz
Tomasz Grodzicki
Tomasz
Grodzicki
Arterial stiffness is not increased in patients with short duration rheumatoid arthritis and ankylosing spondylitis
Taylor & Francis Group
2016
Arterial stiffness
pulse wave velocity
rheumatoid arthritis
ankylosing spondylitis
cardiovascular risk
endothelial markers
augmentation index
2016-09-22 09:25:51
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Arterial_stiffness_is_not_increased_in_patients_with_short_duration_rheumatoid_arthritis_and_ankylosing_spondylitis/3847500
<p>Patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have increased cardiovascular (CV) morbidity and mortality. Arterial stiffness is an independent predictor of CV events. The aim of the study was to assess arterial stiffness and inflammatory markers in patients with short duration chronic arthritis. We assessed carotid-femoral pulse wave velocity (PWV), augmentation index (AIx), traditional CV risk factors and inflammatory and endothelial markers in 71 chronic arthritis patients (RA and AS) and in 29 healthy controls. We did not find differences in PWV (for RA, AS and controls, respectively: 10 [8.8–10.9] versus 10.7 [9.1–11.8] versus 9.2 [8.3–11.4] m/s; <i>p</i> = .14) and AIx (for RA, AS and controls, respectively: 24.3 ± 11.5 versus 5.7 ± 12.4 versus 10 ± 12.8%; <i>p</i> = .22). Both groups of arthritis patients had active disease with significantly elevated inflammatory markers compared to controls. There were no correlations between endothelial and inflammatory markers and parameters of arterial stiffness in arthritis patients. When analyzing arthritis patients according to median of PVW, there were no significant differences in inflammatory and endothelial markers. We found that in patients with short duration active RA and AS arterial stiffness was not increased and furthermore, there was no association between markers of systemic inflammation and arterial stiffness.</p>