Schematic of the translation initiation signaling network. Joshua Lequieu Anirikh Chakrabarti Satyaprakash Nayak Jeffrey D. Varner 10.1371/journal.pcbi.1002263.g001 https://plos.figshare.com/articles/figure/_Schematic_of_the_translation_initiation_signaling_network_/384444 <p>Growth factors trigger receptor dimerization and the formation of adaptor complexes which activate PI3K. PI3K then signals through PIP2/3 to activate Akt. Activated Akt can then activate mTORC1 either directly or by phosphorylating TSC1/2, an inhibitor of Rheb. Activated mTORC1 can phosphorylate 4EBP1 and activate S6K1, two necessary checkpoints for translation initiation. mTORC1 can also phosphorylate IRS-1, a negative feedback which inhibits formation of the adaptor complex and attenuates insulin signaling.</p> 2011-11-10 01:14:04 initiation signaling