OSU53 activates AMPK in human osteoblastic cells.
Dawei Xu
Wei Zhao
Xinhui Zhu
Jianbo Fan
Shengyu Cui
Yuyu Sun
Xiang Chen
Wei Liu
Zhi-ming Cui
10.1371/journal.pone.0162694.g001
https://plos.figshare.com/articles/figure/OSU53_activates_AMPK_in_human_osteoblastic_cells_/3836379
<p>Human osteoblastic OB-6 cells were treated with or without OSU53 (10 μM) for two hours, expression of listed proteins was tested by Western blots (A). p-ACC level (vs. regular ACC) was quantified (B). “Ctrl” stands for untreated control group (Same for all figures). Experiments in this figure were repeated three times, and similar results were obtained. *<i>p</i><0.05 vs. “Ctrl” group (B).</p>
2016-09-15 17:49:48
Dex-induced osteoblastic OB -6 cell death
OSU 53-induced AMPK activation
Dex-treated osteoblastic cells
OSU 53
novel AMPK activator
alleviated Dex-induced oxidative stress
172A
Activating AMPK Signaling Excessive dexamethasone
OB -6 cells
OSU 53-induced actions
OSU 53 Rescues Human OB -6 Osteoblastic Cells
NADPH
OB -6 osteoblastic cells
application causes osteoblast cell death
nicotinamide adenine dinucleotide phosphate
OB -6 cell protection
OSU 53. OSU 53
AMP-activated protein kinase